Prof. Tantillo's research is driven by intriguing mechanistic and structural questions and spans
many areas of organic chemistry. These include natural products synthesis and biosynthesis,
enzyme catalyzed reactions, regio- and stereoselectivity of synthetically useful reactions, and
computer-aided design of enzyme inhibitors and unusual substrates. The primary tool for
tackling mechanistic problems in the Tantillo group is quantum chemistry, although molecular
dynamics simulations and automated docking approaches are also employed.