Fuzheng Guo, Ph.D.

The Guo laboratory studies glial cell biology and pathology in the central nervous system (oligodendroglia, astroglia, and microglia). We aim to discover novel molecular mechanisms underpinning glial cell development, injury, and regeneration in the healthy and diseased central nervous system (CNS). The lab uses a combination of genetic, molecular, cellular, electrophysiological, histological, behavioral, and high-throughput omic approaches to achieve the goal. We use both in vitro culture systems and preclinical animal models of demyelination and white matter injury.